• Evaluation and Prognosis of Copeptin and Coagulation function in Critically ill Patients with severe brain injuryLi Yan1,Cao Fengsheng1, Zhu Wei2*. 1Xiangyang Central Hospital, Xiangyang, Hubei province,440121,China 2Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • 李艳,曹锋生,祝伟.活肽素和凝血功能监测在重型脑外伤病情评估和预后判断中的作用[J].内科急危重症杂志,2017,23(2):
    DOI:
    CN KeyWords:  重型脑外伤  活肽素  凝血功能  APACHE Ⅲ评分
    EN KeyWords:Severe brain injury  Copeptin  Coagulation function  APACHE III score
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    Author:li Yan
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          目的:探索活肽素和凝血功能监测在重型颅脑外伤病情严重程度评估和预后判断中的作用。方法:收集83例重型颅脑外伤患者的临床和实验室检查资料。按照病情严重程度和预后,将患者分别分为不同级别APACHEⅢ评分组、死亡组与存活组、发生器官衰竭组与未发生器官衰竭组,分别比较不同组患者的活肽素水平和凝血功能相关指标。结果:并发MODS者其PLT明显低于未并发MODS者,而FDP、D-dimer明显高于未并发MODS者同时其PT、APTT明显延长,活肽素水平明显高于未发生MODS组;死亡组患者与存活组患者相比,其PLT明显下降,D-dimer明显增高同时PT、APTT明显延长,活肽素水平也明显增加;而且活肽素水平、PLT、PT、APTT、D-dimer异常者其APACHE III评分明显高于正常者(P<0.05)。 结论:活肽素和凝血功能相关指标的水平可以帮助评估重型脑外伤患者的病情严重程度,并判断患者预后。
    EN Abstract:
          Objective To explore the role of copeptin and coagulation function in the evaluation and prognosis of severe brain injury. Methods We collected the clinical and laboratory data of 83 patients with severe brain injury. To analysis the result in the