| 张祖光.脓毒症肠损伤的发病机制及治疗研究进展[J].内科急危重症杂志,2026,32(5):507-511 |
| 脓毒症肠损伤的发病机制及治疗研究进展 |
| Research progress on the pathogenesis and treatment of sepsis-induced intestinal injury |
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| DOI：10.11768/nkjwzzzz.202509221342 |
| 中文关键词: 脓毒症 炎症反应 肠损伤 机制 治疗靶点 |
| 英文关键词: Sepsis Inflammatory response Intestinal Injury Mechanism Therapeutic target |
| 基金项目:内蒙古医学科学院公立医院科研联合基金科技项目（2023GLLH0012）；内蒙古自治区人民医院博士科研启动基金(2024BS07)；内蒙古自治区卫生健康科技计划项目（2025WSJK013;2025WSJK010）；内蒙古自治区自然科学基金项目(2023MS08019；2018LH08002) |
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| 中文摘要: |
| 摘要 脓毒症是由严重感染引起的综合征，可导致器官功能障碍甚至患者死亡。脓毒症引发肠损伤导致细菌和内毒素移位，进一步加重全身炎症反应而促进脓毒症恶化，最终形成恶性循环。目前，脓毒症肠损伤发病机制错综复杂，涉及肠道屏障破坏、微循环障碍、免疫炎症失衡及肠内菌群失调等。本文对脓毒症肠损伤的发病机制及治疗研究进展进行综述，以期为脓毒症肠损伤寻找新的临床治疗方案。 |
| 英文摘要: |
| Abstract Sepsis is a syndrome caused by severe infection, which can lead to organ dysfunction and even patient death. Sepsis causes intestinal damage, leading to the translocation of bacteria and endotoxins, further exacerbating systemic inflammatory response and promoting the deterioration of sepsis, ultimately forming a vicious cycle. At present, the pathogenesis of sepsis-induced intestinal injury is complex, involving disruption of intestinal barrier, microcirculatory disorders, immune inflammation imbalance, and dysbiosis of intestinal microbiota. This article reviews the pathogenesis and treatment research progress of sepsis-induced intestinal injury, in order to find new clinical treatment options for sepsis-induced intestinal injury. |
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