| 郜玲.内质网应激在脓毒症相关急性呼吸窘迫综合征中的研究进展[J].内科急危重症杂志,2026,32(5):490-494 |
| 内质网应激在脓毒症相关急性呼吸窘迫综合征中的研究进展 |
| Research progress on endoplasmic reticulum stress in sepsis-induced acute respiratory distress syndrome |
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| DOI：10.11768/nkjwzzzz.202504020449 |
| 中文关键词: 脓毒症相关急性呼吸窘迫综合征 内质网应激 未折叠蛋白反应 研究进展 |
| 英文关键词: Sepsis -induced acute respiratory distress syndrome Endoplasmic reticulum stress Unfolded protein response Research progress |
| 基金项目:上海市浦东新区科技发展基金事业单位民生科研专项（PKJ2023 -Y12） |
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| 中文摘要: |
| 摘要 脓毒症相关急性呼吸窘迫综合征（ARDS）是一种临床常见的急危重症，其发病机制复杂。近年来，内质网应激（ERs）作为一个重要的调控机制，被认为在脓毒症相关ARDS中发挥着重要作用。ERs通过激活未折叠蛋白反应（UPR）等信号通路调节细胞应激反应，参与调控细胞凋亡、炎症反应及氧化应激反应，从而影响肺组织的损伤和修复过程。本文综述了目前ERs及其相关信号通路在脓毒症相关ARDS中的研究进展，探讨其作为潜在治疗靶点的可能性，以期为该领域的研究和临床干预提供新思路。 |
| 英文摘要: |
| Abstract Sepsis-induced acute respiratory distress syndrome (ARDS) is a common critical illness in clinical practice with a complex pathogenesis. In recent years, endoplasmic reticulum stress (ERs), as an important regulatory mechanism, has been recognized to play a significant role in sepsis-induced ARDS. ERs regulate cellular stress responses by activating signaling pathways such as the unfolded protein response (UPR), thereby participating in the regulation of apoptosis, inflammatory responses, and oxidative stress, and consequently influencing lung tissue injury and repair. This article reviews the current research progress on ERs and its associated signaling pathways in sepsis-induced ARDS and explores their potential as therapeutic targets, with the aim of providing new insights into research and clinical interventions in this field. |
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