| 张双霞.CALM-AF10融合基因阳性的急性白血病患者临床特征[J].内科急危重症杂志,2026,32(5):465-469 |
| CALM-AF10融合基因阳性的急性白血病患者临床特征 |
| Clinical characteristics of acute leukemia patients with positive CALM-AF10 fusion gene |
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| DOI：10.11768/nkjwzzzz.202512111830 |
| 中文关键词: CALM -AF10基因 融合基因 急性白血病 预后 |
| 英文关键词: CALM -AF10 gene Fusion gene Acute leukemia Prognosis |
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| 中文摘要: |
| 摘要 目的：分析CALM-AF10融合基因阳性急性白血病患者的临床特征及结局。方法：回顾性分析5例初诊为CALM-AF10融合基因阳性急性白血病患者的临床资料，结合相关文献总结该类型白血病的实验室检测及临床特征。结果：5例患者中，4例诊断为急性髓系白血病（AML），1例诊断为急性T淋巴细胞白血病/T淋巴母细胞性淋巴瘤（T-ALL/LBL）。5例患者均表达CD33，CD34、CD7阳性率分别为80%、60%；4例AML患者骨髓中异常细胞均表达HLA-DR、CD38、CD33，CD56阳性率为75%（3/4）。尽管T-ALL/LBL患者的原始细胞达到T系评分，但也同时表达了部分髓系标记。3例患者进行了染色体检测，均显示染色体核型异常。5例患者中有4例出现髓外浸润。3例随访的AML患者中，2例经过诱导+巩固强化治疗后未缓解，放弃治疗；1例行异基因造血干细胞移植，3个月后复发。1例T-ALL/LBL患者进行异基因造血干细胞移植，1年后复发，后行CD7嵌合抗原受体T细胞治疗，至随访日仍处于缓解状态。结论：CALM-AF10融合基因阳性急性白血病多伴染色体异常，免疫表型常表现为同时表达髓系及T系标记。该疾病髓外浸润率高，常规治疗反应欠佳，整体预后差。 |
| 英文摘要: |
| Abstract Objective: To analyze the clinical characteristics and outcomes of patients with acute leukemia with CALM-AF10 fusion gene. Methods: A retrospective analysis was conducted on the clinical data of 5 patients initially diagnosed with acute leukemia with positive CALM-AF10 fusion gene. Relevant literature was reviewed to summarize the laboratory tests and clinical characteristics of this type of leukemia. Results: Among the 5 patients, 4 were diagnosed as having acute myeloid leukemia (AML), and 1 having acute T-ymphocytic leukemia/T-lymphoblastic lymphoma (T-ALL/LBL). All 5 patients expressed CD33, and the positive rates of CD34 and CD7 were 80% and 60% respectively. In the bone marrow of 4 AML patients, abnormal cells all expressed HLA-DR, CD38 and CD33, and the positive rate of CD56 was 75% (3/4). Although the primitive cells of T-ALL/LBL patients had a T-lineage score, they also expressed some myeloid markers simultaneously. Chromosome tests were conducted on 3 patients, and all results showed abnormal chromosome karyotypes. Among the 5 patients, 4 cases showed extramedullary infiltration. Among the 3 AML patients who were followed up, 2 cases did not achieve remission after undergoing induction + consolidation intensification therapy, and thus gave up the treatment. One patient underwent allogeneic hematopoietic stem cell transplantation, but relapsed 3 months later. One patient with T-ALL/LBL underwent allogeneic hematopoietic stem cell transplantation. One year later, the disease relapsed and then received CD7 CAR-T therapy. As of the follow-up date, the patient remained in remission. Conclusion: CALM-AF10 fusion gene-positive acute leukemia is often accompanied by chromosomal abnormalities. The immunophenotype usually shows the simultaneous expression of myeloid and T-lineage markers. This disease has a high rate of extramedullary infiltration, and the response to conventional treatment is poor, with a generally poor prognosis. |
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