| 苏艳.急性肺损伤患者近期转归不良的因素分析[J].内科急危重症杂志,2026,32(5):455-459 |
| 急性肺损伤患者近期转归不良的因素分析 |
| Analysis of risk factors for poor short-term outcomes in patients with acute lung injury |
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| DOI：10.11768/nkjwzzzz.202406060417 |
| 中文关键词: 急性肺损伤 转归不良 影响因素 倾向性评分匹配法 |
| 英文关键词: Acute lung injury Poor outcomes Influencing factors Propensity score matching method |
| 基金项目:成都市医学科研课题（2022059） |
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| 摘要点击次数: 7 |
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| 中文摘要: |
| 摘要 目的：基于倾向性评分匹配法（PSM）分析急性肺损伤（ALI）患者近期转归不良的影响因素。方法：回顾性分析116例ALI患者的临床资料，根据入院后28 d转归情况分为不良组（41例）和良好组（75例）。比较匹配前不良组、良好组一般资料；基于PSM法匹配2组资料，比较匹配后不良组（34例）、良好组（34例）一般资料；基于匹配后数据采用Logistic回归模型分析ALI患者近期转归不良的影响因素。结果：116例ALI患者转归不良率35.34%；匹配前不良组年龄大于良好组，糖尿病构成比、肺超声评分高于良好组，氧合指数低于良好组（P均＜0.05）。匹配前、后不良组感染性ALI构成比、C反应蛋白（CRP）、急性生理学与慢性健康状况评估（APACHE Ⅱ）评分高于良好组，白蛋白（Alb）、西维来司他钠治疗构成比低于良好组，凝血酶原时间（PT）、活化部分凝血酶时间（APTT）长于良好组（P均＜0.05）。Logistic回归模型分析显示，感染性ALI（OR=2.332，95%CI：1.372~3.964）、APACHE II评分（OR=3.105，95%CI：1.662~5.802）、Alb（OR=0.532，95%CI：0.347~0.813）、PT（OR=2.487，95%CI：1.327~4.661）、西维来司他钠治疗（OR=0.429，95%CI：0.231~0.795）是ALI患者近期转归不良的影响因素（P均＜0.05）。结论：基于PSM法分析发现，感染性ALI、APACHE II评分、Alb、PT、西维来司他钠治疗是ALI患者近期转归不良的影响因素。 |
| 英文摘要: |
| Abstract Objective: To analyze the influencing factors of poor short-term outcomes in patients with acute lung injury (ALI) based on propensity score matching (PSM). Methods: The clinical data of 116 patients with ALI were retrospectively analyzed. According to their outcomes at 28th day after admission, the patients were divided into a poor outcome group (41 cases) and a good outcome group (75 cases). The general data of the two groups before matching were compared. PSM was used to match the data of the two groups, and the general data of the poor outcome group (34 cases) and the good outcome group (34 cases) after matching were compared. Based on the matched data, a Logistic regression model was used to analyze the influencing factors of poor short-term outcomes in ALI patients. Results: The poor outcome rate of the 116 ALI patients was 35.34%. Before matching, the age, proportion of diabetes, and lung ultrasound score in the poor outcome group were higher than those in the good outcome group, while the oxygenation index was lower than that in the good outcome group (all P< 0.05). Before and after matching, the proportion of infectious ALI, C-reactive protein (CRP), and acute physiological status and chronic health evaluation II (APACHE II) score in the poor outcome group were higher than those in the good outcome group, while albumin (ALB) and the proportion of sivelestat sodium treatment were lower than those in the good outcome group, and prothrombin time (PT) and activated partial thromboplastin time (APTT) were longer than those in the good outcome group (all P< 0.05). Logistic regression analysis showed that infectious ALI (OR=2.332, 95% CI: 1.372-3.964), APACHE II score (OR=3.105, 95% CI: 1.662-5.802), ALB (OR=0.532, 95% CI: 0.347-0.813), PT (OR=2.487, 95% CI: 1.327-4.661), and sivelestat sodium treatment (OR=0.429, 95% CI: 0.231-0.795) were influencing factors for poor short-term outcomes in ALI patients (all P<0.05). Conclusion: Based on PSM analysis, infectious ALI, APACHE II score, ALB, PT, and sivelestat sodium treatment are influencing factors for poor short-term outcomes in ALI patients. |
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