| 房涛.血清微小RNA-326、微小RNA-192水平在良恶性肺结节鉴别中的临床价值[J].内科急危重症杂志,2026,32(4):387-390 |
| 血清微小RNA-326、微小RNA-192水平在良恶性肺结节鉴别中的临床价值 |
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| DOI：10.11768/nkjwzzzz.202409020797 |
| 中文关键词: 微小RNA-326 微小RNA-192 良恶性肺结节 鉴别 |
| 英文关键词: Micro RNA-326 Micro RNA-192 Benign and malignant pulmonary nodules Differentiation |
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| 中文摘要: |
| 摘要 目的：探讨血清微小RNA（miR）-326、miR-192在良恶性肺结节鉴别中的临床价值。方法：选取121例肺结节患者，将其分为良性结节组78例和恶性结节组43例。采用实时荧光定量聚合酶链反应法对2组血清miR-326、miR-192水平进行检测，比较分析2组的临床资料；采用Logistic回归法分析影响恶性结节发生的相关因素；采用Pearson法分析恶性结节患者血清miR-326、miR-192水平相关性。用受试者工作特征（ROC）曲线评估血清miR-326、miR-192水平单独以及二者联合对恶性肺结节的评估价值。结果：恶性结节组血清miR-326水平低于良性结节组（0.79±0.17 vs 1.02±0.18，P＜0.05），miR-192水平高于良性结节组（1.35±0.36 vs 1.01±0.21，P＜0.05）；良性结节组和恶性结节组患者肺结节成分、肺结节密度、肺结节有无实变比较，差异有统计学意义（P均<0.05）；Logistic回归分析显示，miR-326水平是恶性肺结节发生的保护因素（P<0.05），肺结节密度、血清miR-192水平是其危险因素（P<0.05）；Pearson法分析显示，恶性肺结节患者血清miR-326与miR-192水平呈负相关（r=-0.439，P<0.001）；两者单独及联合检测恶性肺结节发生的AUC分别为0.862、0.808和0.930，二者联合诊断优于血清miR-326、miR-192单独诊断（Z二者联合-miR-326=2.719、P=0.007，Z二者联合miR-192=3.159、P= 0.002）。结论：血清miR-326和miR-192水平有助于良恶性肺结节的鉴别诊断。 |
| 英文摘要: |
| Abstract Objective: To investigate the clinical value of serum microRNA (miR)-326 and miR-192 in the differentiation of benign and malignant pulmonary nodules. Methods: Totally, 121 patients with pulmonary nodules were selected, and they were categorized into benign nodule group (n= 78) and malignant nodule group (n= 43). Real-time fluorescence quantitative polymerase chain reaction method was applied to detect the serum levels of miR-326 and miR-192 in each group, and clinical data were compared between two groups. Logistic regression was applied to analyze the relevant factors affecting the occurrence of malignant nodules; Pearson method was applied to analyze the correlation between serum miR-326 and miR-192 levels in patients with malignant nodules. Receiver operating characteristic (ROC) curve was applied to evaluate the diagnostic value of blood levels of miR-326 and miR-192, and their combination for malignant pulmonary nodules. Results: The serum miR-326 level in the malignant nodule group was lower than that in the benign nodule group (0.79±0.17 vs. 1.02±0.18, P< 0.05), while the miR-192 level was higher than that in the benign nodule group (1.350.36 vs. 1.010.21, P< 0.05). There were statistically significant differences in the components of pulmonary nodules, the density of pulmonary nodules, the presence of consolidation in pulmonary nodules, and the levels of serum miR-326 and miR-192 between the benign nodule group and the malignant nodule group (all P< 0.05). Logistic regression analysis showed that miR-326 was a protective factor for the occurrence of malignant pulmonary nodules (P< 0.05), while the density of pulmonary nodules and the level of serum miR-192 were risk factors for the occurrence of malignant pulmonary nodules (P< 0.05). Pearson method analysis results showed that there was an obvious negative correlation between miR-326 level and miR-192 level in patients with malignant pulmonary nodules (r=-0.439, P< 0.001); The AUC of serum miR-326, miR-192 alone and combined detection of malignant pulmonary nodules was 0.862, 0.808 and 0.930, respectively, suggesting the combined diagnosis of the two was superior to the individual diagnosis of serum miR-326 and miR-192 (Zcombination-miR-326=2.719, P= 0.007, Zcombination-miR-192=3.159, P = 0.002). Conclusion: Serum miR-326 and miR-192 are helpful for the differential diagnosis of benign and malignant pulmonary nodules. |
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