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彭敏.血液恶性肿瘤患者血流感染机制、病原学特征及预测模型研究进展[J].内科急危重症杂志,2026,32(3):284-289
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| DOI：10.11768/nkjwzzzz20260316 |
| 中文关键词: 血液恶性肿瘤 血流感染 机制 病原学 预测模型 |
| 英文关键词:Hematological malignancies Bloodstream infection Mechanism Pathogen characteristics Predictive models |
| 基金项目:武汉市卫健委西医科研项目(S202401130050); 武汉市卫健委科研项目(WX21C23) |
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| 全文下载次数: 84 |
| 中文摘要: |
| 摘要 血液恶性肿瘤患者因疾病本身及治疗过程导致的免疫功能严重受损，血流感染发生率高，且病死率显著升高，已成为临床治疗中的主要难题。本文系统综述血液恶性肿瘤患者血流感染的发病机制、病原学特征、耐药情况以及相关炎症标志物和预测模型的研究进展，旨在为临床诊疗和感染管理提供科学依据，推动精准抗感染策略的实施。 |
| 英文摘要: |
| Abstract Patients with hematological malignancies are highly susceptible to bloodstream infections (BSIs) due to profound immunosuppression caused by both the disease itself and treatment-related factors. BSI in this population are associated with high incidence and significantly increased mortality, representing a major challenge in clinical management. This review systematically summarizes recent advances in the pathogenesis, pathogen distribution, antimicrobial resistance, as well as related inflammatory biomarkers and predictive models of BSI in patients with hematological malignancies, aiming to provide a scientific basis for clinical diagnosis, treatment, and infection management, and to promote the implementation of precision anti-infective strategies. |
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